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Interestingly ATM deficient patients can sometimes present with early aging phenotypes including canities or with the pigment disorder vitiligo 56 and mice lacking ATM can also display coat and tail pigmentation abnormalities particularly after genotoxic insult 59

However many antidepressants inhibit CYP2D6 to various extents, which can interfere with the conversion of tamoxifen to endoxifen 49, 50,51 (see diagram)

For this analysis, we used three online resources: (1) NetCorona (cbs.dtu.dk/services/NetCorona) ( pro cleavage sites in coronaviruses (although not limited to just the SARS type coronaviruses), (2) PROSPER, the Protease Specificity Prediction Server (prosper.erc.monash.edu.au) ( pro cleavage site consensus as shown in Figures 1A,B

doi: 10.1016/j.immuni.2013.04.005 10 WestAPShadelGSGhoshS